Each summer, the museum mounts a temporary exhibit that interprets a story of the Oil Region. Past offerings have included an exhibit about early Pennzoil and Quaker State product advertising, a pictorial display highlighting early oil country's industrial dependence on the Allegheny River for transport of goods to market and an exhibit of artifacts and archival materials from the Oil Well Supply Company. In the summer of 1996, the museum will feature artifacts from an historic 19th century Emlenton, Pa. pharmacy known as the Glosser-Crawford-Piroch Pharmacy. Items on display will include personalized Glosser bottle labels from the late 1800's, an original herbal chest with drawers, old laboratory equipment, an early cast iron suppository maker, graduals, mortars and pestles, early medicine bottles, medicated vapor bottles, a World War I military surgical kit and many other items that have been retained at the Emlenton site from the late 19th century to the present.
The focus of the museum is on the local and oil history of Northwestern Pa. and interpreting sites within this area. Concern for the environment, ecology, wildlife reintroduction and increased recreational access to that portion of the Allegheny River that flows through Venango County is also a major interest. The museum plays an active role in the economic development of the Oil Region as a key cultural tourism destination.